PDX Mouse Trial

 

Mouse trial design

• Multiple models; 2-20 arms; 1-5 mice/group

Mouse trial types

• Signal search
  • Screen multiple test articles in a specific cancer type
  • Screen one test article in multiple cancer types
• Proof-of-Concept test
  • Test a single drug (or combination) in multiple models of one cancer type
    • Response survey
    • Biomarker analysis
• Efficacy evaluation
  • Compare and combine a new drug with SOC
  • Test different doses
• Combination selection
  • Test combinations with different chemos or different targeted drugs