January 2, 2016

PDX Mouse Trial

PDX Mouse Trial


Mouse trial design

  • Multiple models; 2-20 arms; 1-5 mice/group

Mouse trial types

  • Signal search
    • Screen multiple test articles in a specific cancer type
    • Screen one test article in multiple cancer types
  • Proof-of-Concept test
    • Test a single drug (or combination) in multiple models of one cancer type
      • Response survey
      • Biomarker analysis
  • Efficacy evaluation
    • Compare and combine a new drug with SOC
    • Test different doses
  • Combination selection
    • Test combinations with different chemos or different targeted drugs
CHINA: 590 RuiQing Road, Building 7, 5F Zhangjiang Hi-Tech Park (East), 201201, Shanghai
US: 1455 Adams Drive, Menlo Park CA 94025